PURL Example
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| The PURLS system was developed in a collaborative partnership of the Family Physicians Inquiries Network (FPIN) and The Journal of Family Practice. |
Annual zoledronic acid infusion lowers risk of fracture, death
Practice Changer: For patients with a recent hip fracture, intravenous zoledronic acid annually is an option for reducing the risk of new fractures and death.1
Strength of recommendation (SOR)
B: based on one well-designed randomized controlled trial
Lyles KW, C olon-Emeric C S, M agaziner JF, et al. Zoledronic acid and clinical fractures and
mortality after hip fracture. N Engl J
Illustrative case: A 75-year-old woman comes to see you 1 month after she had surgery to repair a hip fracture. She was diagnosed with osteoporosis 3 years prior to the hip fracture and is currently taking calcium and vitamin D. She tried taking an oral bisphosphonate but couldn’t tolerate the gastrointestinal side effects. What treatment can you recommend to reduce her risk of sustaining another fracture?
Link to full article
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